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FREQUENT BLOOD DONATION MAY LEAD TO RESTLESS LEGS SYNDROME

DEAR MAYO CLINIC: For years I have given blood every time the blood mobile comes around, but last time a curious thing happened. The nurse asked me if I ever experienced symptoms of restless legs. What was she talking about? She also said I should take a break from blood donations for a month or two. Why? I thought there was a shortage of blood, and I was helping out. — Milwaukee

ANSWER: You are very generous to donate blood frequently, and your gift of blood is a precious resource. However, frequent blood donation can deplete the body’s iron stores and lead to iron deficiency.

This is important because a recently published Mayo Clinic study found an association between iron deficiency caused by frequent blood donation — defined as donation more than three times a year for at least three years — and restless legs syndrome. The good news is that when patients in the study received iron-replacement therapy, the symptoms of RLS disappeared or were markedly improved.

RLS is a disorder characterized by unpleasant sensations in the calves of the legs when the person sits or lies down for an extended period. The sensations are often described as a tingling, aching, crawling or creeping feeling. Because the symptoms occur primarily at night, many patients with RLS suffer from insomnia, which jeopardizes overall health. Symptoms generally improve when the person stands up and moves around.

According to the Restless Leg Syndrome Foundation, up to 8 percent of the U.S. population may suffer from this condition. While many people have only a mild form of the disorder, the foundation estimates that RLS severely affects the lives of millions of individuals.

People with RLS have decreased iron stores in the brain, which appears to be responsible for the majority of symptoms. If you develop symptoms of restless legs, you should temporarily stop donating blood and see your doctor.

In general, it’s a good idea for frequent blood donors with restless legs to have their iron levels measured periodically through a serum ferritin test. People with serum ferritin concentrations of less than 50 mcg/L should not donate blood until their iron stores are replenished.

— Michael Silber, M.D., Neurology, Mayo Clinic, Rochester, Minn.

Additional Resources:
Restless Leg Syndrome and Blood Donation
Appointment Information
More Information on Restless Leg Syndrome

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